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Un savoir-faire unique en thérapie cellulaire

Des technologies développées dans le respect de l’éthique et du bien-être animal

Des produits cellulaires d’origine néonatale

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Un nombre conséquent d’études ont été publiées sur les propriétés des cellules souches et sur leur utilisation, notamment dans des journaux à comité de lecture internationaux. Vetbiobank a contribué à la rédaction de certaines de ces publications.

Publications avec la contribution de Vetbiobank

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A – Les cellules stromales mésenchymateuses

A – Les cellules stromales mésenchymateuses

: 2001-2018 - état des lieux d’une innovation thérapeutique en santé animale et point de vue de l’industrie. Stéphane MADDENS, Éric VIGUIER, Jean Luc CADORE. Bull. Acad. Vét. France. 2018.

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B – Evaluation of the Effect of a Single intra-articular injection of allogeneic neonatal Mesenchymal Stromal Cells Compared to Oral non-Steroidal anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau leveling Osteotomy: a Pilot Study.

B – Evaluation of the Effect of a Single intra-articular injection of allogeneic neonatal Mesenchymal Stromal Cells Compared to Oral non-Steroidal anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau leveling Osteotomy: a Pilot Study.

Mathieu Taroni, Quentin Cabon, Marine Fèbre, Thibaut Cachon1, Nathalie Saulnier, Claude Carozzo, Stéphane Maddens, Fabrice Labadie, Clément Robert Eric Viguier. Frontiers in Veterinary Science . Juin 2017.

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C – Long-Term Safety and Efficacy of Single or Repeated Intra-Articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells for Managing Pain and Lameness in Moderate to Severe Canine Osteoarthritis Without Anti-inflammatory Pharmacological Support: Pilot Clinical Study.

C – Long-Term Safety and Efficacy of Single or Repeated Intra-Articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells for Managing Pain and Lameness in Moderate to Severe Canine Osteoarthritis Without Anti-inflammatory Pharmacological Support: Pilot Clinical Study.

Quentin Cabon, Marine Febre, Niels Gomez, Thibaut Cachon, Paul Pillard, Claude Carozzo, Nathalie Saulnier, Clément Robert, Véronique Livet, Rodolphe Rakic, Nadia Plantier, Philippe Saas, Stéphane Maddens, Eric Viguier. Frontiers in Veterinary Science. Février 2019.

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D – Que pouvons-nous espérer des cellules stromales mésenchymateuses dans le traitement des affections articulaires ?

D – Que pouvons-nous espérer des cellules stromales mésenchymateuses dans le traitement des affections articulaires ?

Olivier M. Lepage, Stéphane Maddens, Christian Jorgensen. Pratique vétérinaire équine. 2015.

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E – Comparison of efficacy and safety of single versus repeated intra-articular injection of allogeneic neonatal mesenchymal stem cells for treatment of osteoarthritis of the metacarpophalangeal/metatarsophalangeal joint in horses: A clinical pilot study.

E – Comparison of efficacy and safety of single versus repeated intra-articular injection of allogeneic neonatal mesenchymal stem cells for treatment of osteoarthritis of the metacarpophalangeal/metatarsophalangeal joint in horses: A clinical pilot study.

Carmelo Magri, Michael Schramme, Marine Febre, Eddy Cauvin, Fabrice Labadie, Nathalie Saulnier, Isé François, Antoine Lechartier, David Aebischer, Anne-Sophie Moncelet, Stéphane Maddens. Plos One. 29 Août 2019.

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F – Canine placenta: A promising potential source of highly proliferative and immunomodulatory mesenchymal stromal cells?

F – Canine placenta: A promising potential source of highly proliferative and immunomodulatory mesenchymal stromal cells?

Nathalie Saulnier, Julia Loriau, Marine Febre, Clément Robert, Rodolphe Rakic, Tancrède Bonte, Samuel Buff, Stéphane Maddens. Veterinary Immunology and Immunopathology. 2016.

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G – Intra- articular administration of xenogeneic neonatal Mesenchymal Stromal Cells early after meniscal injury down-regulates metal- loproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis.

G – Intra- articular administration of xenogeneic neonatal Mesenchymal Stromal Cells early after meniscal injury down-regulates metal- loproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis.

Saulnier N, Viguier E, Perrier-Groult E, Chenu C, Pillet E, Roger T, et al. Osteoarthr Cartil. 2015.

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H – RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation

H – RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation

- Rodolphe Rakic, Bastien Bourdon, Magalie Hervieu, Thomas Branly, Florence Legendre, Nathalie Saulnier, Fabrice Audigié, Stéphane Maddens, Magali Demoor, Philippe Galera - Int. J. Mol. Sci. 2017

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I – Differences in the intrinsic chondrogenic potential of equine umbilical cord matrix and cord blood mesenchymal stromal/stem cells for cartilage regeneration

I – Differences in the intrinsic chondrogenic potential of equine umbilical cord matrix and cord blood mesenchymal stromal/stem cells for cartilage regeneration

- Rodolphe Rakic, Bastien Bourdon, Magali Demoor, Stéphane Maddens, Nathalie Saulnier, Philippe Galéra Scientific Reports. 2018.

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J – Biosafety evaluation of equine umbilical cord-derived mesenchymal stromal cells (UC-MSCs) by systematic pathogen screening in peripheral maternal blood and paired UC-MSCs

J – Biosafety evaluation of equine umbilical cord-derived mesenchymal stromal cells (UC-MSCs) by systematic pathogen screening in peripheral maternal blood and paired UC-MSCs

- Denys, A - Léon, A - Robert, C - Saulnier, N - Josson-Schramme, A - Legrand, L -Wimel, L - Maddens, S – Pronost,

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K – Lacérations cornéennes profondes chez le cheval : intérêt du recouvrement par une membrane amniotique

K – Lacérations cornéennes profondes chez le cheval : intérêt du recouvrement par une membrane amniotique

Emilie Quéré, Coline Jondeau, Sabine Chahory. Pratique Vétérinaire Equine 2021 n°211.

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L- Mesenchymal stem cell transplantation into the spinal cord of healthy adult horses undergoing cervical ventral interbody fusion.

L- Mesenchymal stem cell transplantation into the spinal cord of healthy adult horses undergoing cervical ventral interbody fusion.

Isé François, Olivier M. Lepage, Elaine Carpenter, Isabelle Desjardins, Cécile De Guio, Inga-Catalina Cruz Benedetti, Stéphane Maddens, Nathalie Saulnier, Barrie D. Grant. Veterinary Surgery 2021

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$M- Placenta-derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018). Journal of Small Animal Practice. 2022.$

M- Placenta-derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018). Journal of Small Animal Practice. 2022.

M. Febre, N. Saulnier, P. Roux, F. Boutoille, N. Girard, C. Robert, R. Rakic, E. Rosset and S. Maddens.

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Autres publications internationales dans la littérature

Sélection de publications sur les propriétés des cellules souches

01 – A prospective, randomized, masked, and placebo-controlled efficacy study of intraarticular allogeneic adipose stem cells for the treatment of osteoarthritis in dogs.

01 – A prospective, randomized, masked, and placebo-controlled efficacy study of intraarticular allogeneic adipose stem cells for the treatment of osteoarthritis in dogs.

Robert Harman, Kim Carlson, Jamie Gaynor Scott Gustafson, Sarit Dhupa, Keith Clement, Michael Hoelzler, Tim McCarthy, Pamela Schwartz and Cheryl Adams. Frontiers in Veterinary Science. Septembre 2016.

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02 – Assessment of the effect of intraarticular injection of auto-logous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis.

02 – Assessment of the effect of intraarticular injection of auto-logous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis.

Vilar JM, Batista M, Morales M, Santana A, Cuervo B, Rubio M, et al. BMC Vet Res. 2014.

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03 – Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs.

03 – Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs.

Vilar JM, Morales M, Santana A, Spinella G, Rubio M, Cuervo B, et al. BMC Vet Res. 2013.

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04 – Hip osteoarthritis in dogs: a randomized study using mesenchymal stem cells from adipose tissue and plasma rich in growth factors.

04 – Hip osteoarthritis in dogs: a randomized study using mesenchymal stem cells from adipose tissue and plasma rich in growth factors.

Cuervo B, Rubio M, Sopena J, Dominguez JM, Vilar J, Morales M, et al. Int J Mol Sci. 2014.

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05 – Therapeutic effect of adipose-derived mesenchymal stem cell injection in horses suffering from bone spavin.

05 – Therapeutic effect of adipose-derived mesenchymal stem cell injection in horses suffering from bone spavin.

Nicpoń J, Marycz K, Grzesiak J. Pol J Vet Sci. 2013.

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06 – Regenerative Therapies for Equine Degenerative Joint Disease: A Preliminary Study.

06 – Regenerative Therapies for Equine Degenerative Joint Disease: A Preliminary Study.

Broeckx S, Zimmerman M, Crocetti S, Suls M, Mariën T, Ferguson SJ, et al. PLOS ONE. 2014.

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07 – Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury.

07 – Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury.

Ferris DJ, Frisbie DD, Kisiday JD, McIlwraith CW, Hague BA, Major MD, et al. Vet Surg. 2014.

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08 – Investigation of the immune response to autologous, allogeneic, and xenogeneic mesenchymal stem cells after intra-articular injection in horses.

08 – Investigation of the immune response to autologous, allogeneic, and xenogeneic mesenchymal stem cells after intra-articular injection in horses.

Pigott JH, Ishihara A, Wellman ML, Russell DS, Bertone AL. Veterinary Immunology and Immunopathology. 2013.

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09 – In Vitro Analysis of Equine, Bone Marrow-Derived Mesenchymal Stem Cells Demonstrates Differences Within Age- And Gender-Matched Horses.

09 – In Vitro Analysis of Equine, Bone Marrow-Derived Mesenchymal Stem Cells Demonstrates Differences Within Age- And Gender-Matched Horses.

J L Carter-Arnold, N L Neilsen, L L Amelse, A Odoi, M S Dhar. Equine Vet J. Septembre 2014.

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10 – Characterization and Profiling of Immunomodulatory Genes of Equine Mesenchymal Stromal Cells From Non-Invasive Sources.

10 – Characterization and Profiling of Immunomodulatory Genes of Equine Mesenchymal Stromal Cells From Non-Invasive Sources.

Catharina De Schauwer, Karen Goossens, Sofie Piepers, Maarten K Hoogewijs, Jan L J Govaere, Katrien Smits, Evelyne Meyer, Ann Van Soom, Gerlinde R Van de Walle. Stem Cell Res Ther. Janvier 2014.

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$11 – Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis: Allogeneic Stem Cell Therapy for Feline Oral Inflammation.$

11 – Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis: Allogeneic Stem Cell Therapy for Feline Oral Inflammation.

Arzi B, Clark KC, Sundaram A, Spriet M, Verstraete FJM, Walker NJ, et al. STEM CELLS Translational Medicine. 2017.

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$12 – Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats: Autologous CSMs for Severe Refractory FCGS$

12 – Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats: Autologous CSMs for Severe Refractory FCGS

Arzi B, Mills-Ko E, Verstraete FJM, Kol A, Walker NJ, Badgley MR, et al. Therapeutic Efficacy of Fresh. STEM CELLS Translational Medicine. 2016.

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$13 – Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety.$

13 – Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety.

Villatoro AJ, Hermida-Prieto M, Fernández V, Fariñas F, Alcoholado C, Rodríguez-García MI, Mariñas-Pardo L, Becerra J. Vet Rec. 2018.

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14 – Use of adipose-derived mesenchymal stem cells in keratoconjunctivitis sicca in a canine model.

14 – Use of adipose-derived mesenchymal stem cells in keratoconjunctivitis sicca in a canine model.

Villatoro AJ, Fernández V, Claros S, Rico- Llanos GA, Becerra J, Andrades JA. Biomed Res Int. 2015.

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15 – Hypoxia-enhanced Wound-Healing Function of Adipose-Derived Stem Cells: Increase in Stem Cell Proliferation and Up-Regulation of VEGF and bFGF.

15 – Hypoxia-enhanced Wound-Healing Function of Adipose-Derived Stem Cells: Increase in Stem Cell Proliferation and Up-Regulation of VEGF and bFGF.

Eun Young Lee, Ying Xia, Won-Serk Kim, Myoung Hee Kim, Tae Hwan Kim, Kea Jeung Kim, Byung-Soon Park, Jong-Hyuk Sung. Wound Repair Regen. Juil-août 2009.

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16 – Interaction of Human Mesenchymal Stem Cells With Cells Involved in Alloantigen-Specific Immune Response Favors the Differentiation of CD4+ T-cell Subsets Expressing a regulatory/suppressive Phenotype.

16 – Interaction of Human Mesenchymal Stem Cells With Cells Involved in Alloantigen-Specific Immune Response Favors the Differentiation of CD4+ T-cell Subsets Expressing a regulatory/suppressive Phenotype.

Rita Maccario, Marina Podestà, Antonia Moretta, Angela Cometa, Patrizia Comoli, Daniela Montagna, Liane Daudt, Adalberto Ibatici, Giovanna Piaggio, Sarah Pozzi, Francesco Frassoni, Franco Locatelli. Haematologica. Avril 2005.

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17 – Immunogenicity of Adult Mesenchymal Stem Cells: Lessons from the Fetal Allograft.

17 – Immunogenicity of Adult Mesenchymal Stem Cells: Lessons from the Fetal Allograft.

Barry FP, Murphy JM, English K, Mahon BP. Stem Cells and Development. 2005.

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18 – Pro-Inflammatory Cytokines, IFN and TNF, Influence Immune Properties of Human Bone Marrow and Wharton Jelly Mesenchymal Stem Cells Differentially.

18 – Pro-Inflammatory Cytokines, IFN and TNF, Influence Immune Properties of Human Bone Marrow and Wharton Jelly Mesenchymal Stem Cells Differentially.

Prasanna SJ, Gopalakrishnan D, Shankar SR, Vasandan AB. PLOS ONE. 2010.

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19 – Safety and efficacy of allogeneic adipose tissue-derived mesen-chymal stem cells for treatment of dogs with inflammatory bowel disease: Endoscopic and histological outcomes.

19 – Safety and efficacy of allogeneic adipose tissue-derived mesen-chymal stem cells for treatment of dogs with inflammatory bowel disease: Endoscopic and histological outcomes.

Pérez-Merino EM, Usón-Casaús JM, Duque- Carrasco J, Zaragoza-Bayle C, Mariñas-Pardo L, Hermida-Prieto M, et al. Vet J. 2015a;206:391– 7.

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20 – Safety and efficacy of allogeneic adipose tissue-derived mesen- chymal stem cells for treatment of dogs with inflammatory bowel disease: Clinical and laboratory outcomes.

20 – Safety and efficacy of allogeneic adipose tissue-derived mesen- chymal stem cells for treatment of dogs with inflammatory bowel disease: Clinical and laboratory outcomes.

Pérez-Merino EM, Usón-Casaús JM, Zaragoza- Bayle C, Duque-Carrasco J, Mariñas-Pardo L, Hermida-Prieto M, et al. Vet J. 2015b;206:385– 90.

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21 – Stem cell therapy in cats with chronic enteropathy: a proof-of-concept study.

21 – Stem cell therapy in cats with chronic enteropathy: a proof-of-concept study.

Webb TL,Webb CB. J Feline Med Surg. 2015;17:901–8.

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22 – Transplantation of amniotic membrane-derived multipotent cells ameliorates and delays the progression of chronic kidney disease in cats.

22 – Transplantation of amniotic membrane-derived multipotent cells ameliorates and delays the progression of chronic kidney disease in cats.

Vidane AS, Pinheiro AO, Casals JB, Passarelli D, Hage M, Bueno RS, et al. Reprod Domest Anim. 2017;52 Suppl 2:316–26.

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23 – Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials.

23 – Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials.

Lalu MM, McIntyre L, Pugliese C, Fergusson D, Winston BW, Marshall JC, et al. PLoS ONE. 2012;7:e47559.

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24 – Multiple intravenous injections of allogeneic equine mesenchymal stem cells do not induce a systemic inflammatory response but do alter lymphocyte subsets in healthy horses.

24 – Multiple intravenous injections of allogeneic equine mesenchymal stem cells do not induce a systemic inflammatory response but do alter lymphocyte subsets in healthy horses.

Kol A, Wood JA, Carrade Holt DD, Gillette JA, Bohannon-Worsley LK, Puchalski SM, et al. Stem Cell Res Ther. 2015;6:73.

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25 – A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.

25 – A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.

Centeno CJ, Al-Sayegh H, Freeman MD, Smith J, Murrell WD, Bubnov R. International Orthopaedics. 2016;40:1755– 65.

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26 – Anti-Inflammatory and Immunomodulatory Activities of Stem Cells.

26 – Anti-Inflammatory and Immunomodulatory Activities of Stem Cells.

Peroni JF, Borjesson DL. Veterinary Clinics of North America: Equine Practice. 2011;27:351–62.

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27 – Scintigraphic evaluation of intra-arterial and intrave- nous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using 99mTc-HMPAO: Regional limb perfusion of stem cells.

27 – Scintigraphic evaluation of intra-arterial and intrave- nous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using 99mTc-HMPAO: Regional limb perfusion of stem cells.

Sole A, Spriet M, Galuppo LD, Padgett KA, Borjesson DL, Wisner ER, et al. Equine Veterinary Journal. 2012;44:594–9.

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28 – Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?

28 – Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?

Moll G, Rasmusson-Duprez I, von Bahr L, Connolly-Andersen A-M, Elgue G, Funke L, et al. STEM CELLS. 2012;30:1565–74.

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Product Pipeline

Gamme	Produit	Développement & optimisation	POC	Etude Pilote	Industrialisation / Production	Etude clinique pivot	Enregistrement	Lancement marketing
CANIPREN	CA0101 Arthrose canine	CA0101 Arthrose canine	CA0101 Arthrose canine
	CA0102 Dermatite atopique
	CA0103 Dermatite atopique Maladie Inflammatoire Chronique de l’Intestin

Gamme	Produit	Développement & optimisation	POC	Etude Pilote	Industrialisation / Production	Etude clinique pivot	Enregistrement	Lancement marketing
FELIPREN	FE0101 Gingivostomatite
	FE0102 Insuffisance rénale chronique
	FE0103 Arthrose féline

Gamme	Produit	Développement & optimisation	POC	Etude Pilote	Industrialisation / Production	Etude clinique pivot	Enregistrement	Lancement marketing
EQUIPREN OMBISTEM	EQ0101 Arthrose équine